The Polygenic Score Catalog Calculator is a nextflow pipeline for polygenic score calculation
Self-hosted genetics processing platform: VCF generation, imputation merging, PGS calculation. 60× faster than R, LUKS encrypted, air-gapped worker. Rust + PostgreSQL.
A local, native genome browser, variant explorer, plasmid designer, CRISPR studio, and polygenic-risk tool — your DNA stays on your machine.
Turn raw 23andMe/AncestryDNA data into a private, local HTML health report — clinical variants (ClinVar, AlphaMissense), pharmacogenomics (PharmGKB), and polygenic risk scores (PGS Catalog), plus an optional AI summary. Runs 100% locally; your genome is never uploaded.
Polygenic risk score calculator from GWAS summary statistics
Statistical genetics pipeline for patient stratification and clinical trial enrichment using polygenic risk scores.
Reproducible bash-in-Jupyter tutorial for Illumina SNP microarray genotyping pipeline: IDAT → GTC → VCF → PLINK. Foundation for population-scale precision medicine and polygenic risk scoring workflows.
Polygenic Risk Score calculator for Alzheimer's Disease based on de Rojas et al. (2021, Nature Communications). Calculates individual AD risk from VCF genotype data.
Self-hosted, local-first whole-genome annotation pipeline (ClinVar, PGS, pharmacogenomics, SV triage, mtDNA, SNPedia). Your DNA never leaves your machine.
Polygenic risk score (PGS Catalog PGS000055) computed from real 1000 Genomes genotypes, an ancestry-transferability analysis, and ML classifiers (logistic regression, gradient boosting) evaluating a calibrated simulated cancer cohort.
Add a description, image, and links to the polygenic-risk-score topic page so that developers can more easily learn about it.
To associate your repository with the polygenic-risk-score topic, visit your repo's landing page and select "manage topics."