Error

[jeslo328]

Hi
can anyone advice on the below error

NA Requesting an AUC range starting (0) before the first measurement (0.019) is not allowed

PKNCAdata(o_conc, o_dose,
                               intervals=data.frame(start=0, # Change 1 
                                                    end=c(3,24),  # 0-3 hours or 0-24 or 0- 168
                                                    cmax=T,
                                                    cmin=T,
                                                    cav=T,
                                                    tmax=T,
                                                    half.life=T,
                                                    aucall=TRUE,
                                                    auclast=TRUE,
                                                    aucinf.pred=TRUE,
                                                    aucinf.obs=TRUE))

[billdenney]

You don't have a measurement at time 0, so it doesn't know how to calculate the AUC (is it single-dose, multiple dose, etc.). I assume that you want it to assume a concentration of 0 at time 0, so you will need to give an imputation method as described here (https://cran.r-project.org/web/packages/PKNCA/vignettes/v08-data-imputation.html#imputation-for-the-full-dataset). I have added it to your code below.

PKNCAdata(o_conc, o_dose,
                               intervals=data.frame(start=0, # Change 1 
                                                    end=c(3,24),  # 0-3 hours or 0-24 or 0- 168
                                                    cmax=T,
                                                    cmin=T,
                                                    cav=T,
                                                    tmax=T,
                                                    half.life=T,
                                                    aucall=TRUE,
                                                    auclast=TRUE,
                                                    aucinf.pred=TRUE,
                                                    aucinf.obs=TRUE),
  impute = "start_predose,start_conc0"
)